SCHEMBL5788935

SCHEMBL5788935

COc1cc(CCO)cc(OC)c1-c1ccc(C[C@H](NC(=O)c2c(Cl)cccc2Cl)C(=O)O)cc1

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 20/20 0.65
ITGB7 P26010 19/20 0.65
ITGB1 P05556 18/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5785174 0.91 ITGA4 (0.70) ITGA4ITGB7ITGB1
SCHEMBL6504143 0.90 ITGA4 (0.55) ITGA4ITGB7ITGB1
SCHEMBL919561 0.89 ITGA4 (0.66) ITGA4ITGB7ITGB1
SCHEMBL5784609 0.89 ITGA4 (0.68) ITGA4ITGB7ITGB1
SCHEMBL5787036 0.89 ITGA4 (0.68) ITGA4ITGB7ITGB1
SCHEMBL919261 0.89 ITGA4 (0.61) ITGA4ITGB7ITGB1
SCHEMBL1222489 0.89 ITGA4 (0.74) ITGA4ITGB7ITGB1
SCHEMBL1222491 0.89 ITGA4 (0.74) ITGA4ITGB7ITGB1
SCHEMBL5783429 0.89 ITGB1 (0.64) ITGA4ITGB7ITGB1
SCHEMBL5782470 0.89 ITGA4 (0.65) ITGA4ITGB7ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1049662-B1 INHIBITORS OF ALPHA4 MEDIATED CELL ADHESION TANABE SEIYAKU CO (JP) 2006-06-21 EP disclosed