SCHEMBL5788964

SCHEMBL5788964

CC(C)C(=O)N(C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.63

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 9/20 0.63
MLYCD O95822 3/20 0.55
P2RX1 P51575 1/20 0.48
HDAC8 Q9BY41 1/20 0.43
CES2 O00748 1/20 0.42
S1PR1 P21453 1/20 0.39
MAPT P10636 1/20 0.39
ALDH1A1 P00352 1/20 0.38
POLQ O75417 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28746553 0.83 MLYCD (0.54) TACR1MLYCDCES2MAPTALDH1A1
SCHEMBL11006983 0.81 TACR1 (0.57) TACR1P2RX1CES2MAPT
SCHEMBL18935755 0.80 MLYCD (0.50) TACR1MLYCDALDH1A1
SCHEMBL15397669 0.79 TACR1 (0.59) TACR1P2RX1CES2MAPTPOLQ
SCHEMBL12435510 0.78 TACR1 (0.54) TACR1MLYCDP2RX1CES2MAPT
SCHEMBL11406952 0.75 TACR1 (0.60) TACR1P2RX1CES2POLQ
SCHEMBL12513373 0.75 TACR1 (0.51) TACR1MLYCDP2RX1HDAC8CES2
SCHEMBL12587114 0.74 TACR1 (0.50) TACR1P2RX1CES2MAPTPOLQ
SCHEMBL4555019 0.72 MAPT (0.56) TACR1MLYCDP2RX1MAPTALDH1A1
SCHEMBL12435720 0.72 TACR1 (0.50) TACR1MLYCDP2RX1HDAC8CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1643998-A1 DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA F. HOFFMANN-LA ROCHE AG (CH) 2006-04-12 EP claimed
WO-2005002577-A1 DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA F. HOFFMANN-LA ROCHE AG (CH) 2005-01-13 WO claimed
EP-1643998-A1 DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA F. HOFFMANN-LA ROCHE AG (CH) 2006-04-12 EP disclosed
WO-2005002577-A1 DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA F. HOFFMANN-LA ROCHE AG (CH) 2005-01-13 WO disclosed