Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.62 |
| ▸ | ELANE | P08246 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752612 | 0.90 | NOTUM (0.76) | NOTUMELANELMNAMAPTPOLB | |
| SCHEMBL29808797 | 0.90 | NOTUM (0.76) | NOTUMELANELMNAMAPTPOLB | |
| SCHEMBL4022781 | 0.83 | NOTUM (0.63) | NOTUMELANELMNAMAPTPOLB | |
| SCHEMBL4152306 | 0.83 | NOTUM (0.62) | NOTUMELANELMNAMAPTPOLB | |
| SCHEMBL8065166 | 0.82 | NOTUM (0.65) | NOTUMELANELMNAMAPTPOLB | |
| SCHEMBL984085 | 0.81 | NOTUM (0.64) | NOTUMELANELMNAMAPTPOLB | |
| SCHEMBL29875297 | 0.81 | ELANE (0.75) | ELANE | |
| SCHEMBL560793 | 0.81 | ELANE (0.75) | ELANE | |
| SCHEMBL4157208 | 0.80 | NOTUM (0.56) | NOTUMELANELMNAMAPTPOLB | |
| SCHEMBL8063220 | 0.80 | NOTUM (0.61) | NOTUMELANELMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663974-A1 | 2-PYRIDONE DERIVATIVES AS NETROPHIL ELASTASE INHIBITORS AND THEIR USE | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026124-A1 | 2-PYRIDONE DERIVATIVES AS NETROPHIL ELASTASE INHIBITORS AND THEIR USE | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |