Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785586 | 0.89 | GPR119 (0.50) | GPR119KMT2AABL1RIN1KDM4E | |
| SCHEMBL20076232 | 0.84 | GPR119 (0.64) | TP53MAPTTHRBGPR119KMT2A | |
| SCHEMBL22556816 | 0.81 | GPR119 (0.58) | TP53MAPTTHRBGPR119KMT2A | |
| SCHEMBL22556819 | 0.81 | GPR119 (0.58) | TP53MAPTTHRBGPR119KMT2A | |
| SCHEMBL240683 | 0.78 | GPR119 (0.61) | GPR119KMT2AALDH1A1PDE4APDE4B | |
| SCHEMBL3166775 | 0.78 | GPR119 (0.50) | TP53MAPTTHRBGPR119KMT2A | |
| SCHEMBL3485718 | 0.78 | GPR119 (0.78) | TP53MAPTTHRBGPR119KMT2A | |
| SCHEMBL17572994 | 0.76 | HDAC4 (0.60) | TP53MAPTTHRBKMT2AKDM4E | |
| SCHEMBL18824369 | 0.76 | KMT2A (0.58) | GPR119KMT2AABL1RIN1KDM4E | |
| SCHEMBL1198897 | 0.76 | NAMPT (0.60) | TP53MAPTTHRBGPR119KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670783-A2 | ANTITHROMBOTIC AROMATIC ETHERS | ELI LILLY AND COMPANY (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005049604-A2 | ANTITHROMBOTIC AROMATIC ETHERS | ELI LILLY AND COMPANY (US) | 2005-06-02 | — | — | WO | disclosed |