⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12975055 | 0.79 | — | — | |
| SCHEMBL17610936 | 0.79 | TSHR (0.36) | — | |
| SCHEMBL3793444 | 0.77 | — | — | |
| SCHEMBL27854783 | 0.77 | MCL1 (0.35) | — | |
| SCHEMBL5956546 | 0.76 | — | — | |
| SCHEMBL2226469 | 0.75 | MEN1 (0.44) | — | |
| SCHEMBL28561917 | 0.75 | MCL1 (0.33) | — | |
| SCHEMBL15083315 | 0.75 | — | — | |
| SCHEMBL3047206 | 0.74 | — | — | |
| SCHEMBL248088 | 0.73 | DGAT1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359333-B2 | Efficient process for the preparation of Lapatinib and salts thereof by means of new intermediates | F.I.S.—Fabbrica Italiana Sintetiei (IT) | 2016-06-07 | — | — | US | claimed |
| US-20150322050-A1 | Efficient Process for the Preparation of Lapatinib and Salts Thereof by Means of New Intermediates | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-11-12 | — | — | US | claimed |
| US-9169236-B2 | Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates | F.I.S.-Fabbrica Italiana Sintetiei S.p.A. (IT) | 2015-10-27 | — | — | US | claimed |
| EP-2921490-A2 | PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2015-09-23 | — | — | EP | claimed |
| US-20150225376-A1 | Efficient Process for the Preparation of Lapatinib and Salts thereof by Means of New Intermediates | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-08-13 | — | — | US | claimed |
| US-9024023-B2 | Efficient process for the preparation of lapatinib and salts thereof by means of new intermediates | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2015-05-05 | — | — | US | claimed |
| US-20150065710-A1 | EFFICIENT PROCESS FOR THE PREPARATION OF LAPATINIB AND SALTS THEREOF BY MEANS OF NEW INTERMEDIATES | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-03-05 | — | — | US | claimed |
| EP-1102782-B1 | STRUCTURAL ANALOGS OF AMINE BASES AND NUCLEOSIDES | BIO RAD LABORATORIES (US) | 2006-03-29 | — | — | EP | claimed |
| EP-1031379-B1 | Catalyst comprising rutheniumcomplex, and use thereof in hydrogenation of unsaturated substrates, especially organic nitriles | DU PONT (US) | 2002-10-23 | — | — | EP | claimed |
| EP-1031379-A1 | Catalyst comprising rutheniumcomplex, and use thereof in hydrogenation of unsaturated substrates, especially organic nitriles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-08-30 | — | — | EP | claimed |
| EP-0807098-B1 | IMPROVED PROCESS FOR REDUCTIVE HYDROLYSIS OF NITRILES | DU PONT (US) | 1998-09-09 | — | — | EP | claimed |
| US-5741955-A | TRANSITION METAL COMPLEX CATALYST | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1998-04-21 | — | — | US | claimed |
| EP-0807098-A1 | IMPROVED PROCESS FOR REDUCTIVE HYDROLYSIS OF NITRILES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1997-11-19 | — | — | EP | claimed |
| WO-1996023753-A1 | IMPROVED PROCESS FOR REDUCTIVE HYDROLYSIS OF NITRILES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-08-08 | — | — | WO | claimed |
| EP-0270651-B1 | NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES | CALIFORNIA INST OF TECHN (US) | 1994-06-15 | — | — | EP | claimed |
| EP-0270651-A4 | NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. | CALIFORNIA INST OF TECHN (US) | 1989-03-29 | — | — | EP | claimed |
| EP-0270651-A1 | NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. | CALIFORNIA INST OF TECHN (US) | 1988-06-15 | — | — | EP | claimed |
| WO-1988000201-A1 | NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES | CALIFORNIA INSTITUTE OF TECHNOLOGY, INC. (US) | 1988-01-14 | — | — | WO | claimed |
| JP-8217768-A | — | — | None | — | — | JP | disclosed |
| WO-1996023803-A1 | RUTHENIUM HYDROGENATION CATALYSTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-08-08 | — | — | WO | disclosed |