Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KCNN4 | O15554 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29882115 | 0.81 | CHRM3 (0.50) | MAPTKMT2AKCNN4HTTCES1 | |
| SCHEMBL6529365 | 0.80 | MAPT (0.53) | MAPTKMT2AKCNN4HTTCES1 | |
| SCHEMBL9718716 | 0.80 | CES1 (0.56) | MAPTKMT2AKCNN4CES1CYP2C19 | |
| SCHEMBL3837958 | 0.79 | MAPT (0.55) | MAPTKMT2AKCNN4HTTCYP2C19 | |
| SCHEMBL27602772 | 0.79 | MAPT (0.50) | MAPTKMT2AKCNN4HTTCYP2C19 | |
| SCHEMBL13946506 | 0.79 | MAPT (0.55) | MAPTKMT2AKCNN4HTTCYP2C19 | |
| SCHEMBL13946510 | 0.79 | MAPT (0.55) | MAPTKMT2AKCNN4HTTCYP2C19 | |
| SCHEMBL11251 | 0.77 | HTT (0.50) | MAPTKMT2AKCNN4HTTCES1 | |
| SCHEMBL5788809 | 0.77 | MAPT (0.46) | MAPTKMT2AKCNN4HTTCYP2C19 | |
| SCHEMBL3994296 | 0.76 | MAPT (0.57) | MAPTKMT2AKCNN4HTTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636224-A2 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE | Prosidion Limited (GB) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004104001-A2 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE | PROSIDION LIMITED (GB) | 2004-12-02 | — | — | WO | disclosed |