Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 10/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.49 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3103669 | 0.90 | SIRT6 (0.51) | SIRT6POLBFAAHMGLLALDH1A1 | |
| SCHEMBL1140179 | 0.90 | POLB (0.57) | MAPK11MAPK14SIRT6POLBFAAH | |
| SCHEMBL1140167 | 0.89 | MEN1 (0.52) | MAPK11MAPK14SIRT6POLBFAAH | |
| SCHEMBL1140045 | 0.89 | MAPK11 (0.48) | MAPK11MAPK14SIRT6POLBFAAH | |
| SCHEMBL5785750 | 0.88 | SIRT6 (0.47) | MAPK11MAPK14SIRT6POLBFAAH | |
| SCHEMBL1139935 | 0.88 | MAPT (0.54) | MAPK11MAPK14SIRT6POLBALDH1A1 | |
| SCHEMBL1139653 | 0.88 | MAPK11 (0.47) | MAPK11MAPK14SIRT6POLBFAAH | |
| SCHEMBL5786079 | 0.88 | MAPK14 (0.53) | MAPK11MAPK14BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL5785922 | 0.87 | MAPT (0.48) | MAPK11MAPK14SIRT6POLBFAAH | |
| SCHEMBL5788418 | 0.87 | SIRT6 (0.55) | MAPK11MAPK14SIRT6POLBFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682520-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042502-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-12 | — | — | WO | disclosed |