Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL579070 | 0.90 | KMT2A (0.51) | KMT2AAXLHCAR3ADORA3ADORA1 | |
| SCHEMBL579065 | 0.88 | KMT2A (0.49) | KMT2AAXLHCAR3ADORA3ADORA1 | |
| SCHEMBL578863 | 0.85 | ULK1 (0.51) | KMT2AAXLMAPK3AURKAFLT3 | |
| SCHEMBL1934159 | 0.84 | KMT2A (0.69) | KMT2AAXLMAPK3ADORA3ADORA1 | |
| SCHEMBL1937546 | 0.82 | KMT2A (0.71) | KMT2AAXLMAPK3ADORA3ADORA1 | |
| SCHEMBL17923700 | 0.81 | KMT2A (0.49) | KMT2AAXLMAPK3HCAR3ADORA3 | |
| SCHEMBL16513340 | 0.81 | KMT2A (0.49) | KMT2AAXLMAPK3HCAR3ADORA3 | |
| SCHEMBL17923701 | 0.81 | KMT2A (0.49) | KMT2AAXLMAPK3HCAR3ADORA3 | |
| SCHEMBL993784 | 0.81 | KMT2A (0.64) | KMT2AAXLMAPK3LRRK2ADORA3 | |
| SCHEMBL17923704 | 0.79 | KMT2A (0.46) | KMT2AAXLMAPK3LRRK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027107-B1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-02-15 | — | — | EP | disclosed |
| EP-2357181-A1 | 2,4-Diaminopyrimidines as inhibitors of cell cycle kinases | Boehringer Ingelheim International GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |