Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27544533 | 0.98 | DPP4 (0.56) | DPP4LMNAF2TAAR1HTR2A | |
| SCHEMBL13822592 | 0.86 | DPP4 (0.59) | DPP4LMNAF2TAAR1HTR2A | |
| Hydrochloric Acid SCHEMBL11571128 | 0.84 | DPP4 (0.56) | DPP4LMNAF2TAAR1HTR2A | |
| SCHEMBL28416425 | 0.82 | DPP4 (0.54) | DPP4LMNAF2TAAR1HTR2A | |
| SCHEMBL26923438 | 0.81 | TACR1 (0.50) | DPP4LMNAF2TAAR1HTR2A | |
| SCHEMBL7275229 | 0.79 | DPP4 (0.56) | DPP4LMNAF2TAAR1HTR2A | |
| SCHEMBL2192530 | 0.79 | DPP4 (0.56) | DPP4LMNAF2TAAR1ADRA2A | |
| SCHEMBL8241991 | 0.79 | ADRB2 (0.54) | LMNAHIF1AKDM4E | |
| SCHEMBL2768382 | 0.79 | ADRB2 (0.54) | LMNAHIF1AKDM4E | |
| SCHEMBL10159454 | 0.79 | TAAR1 (0.46) | DPP4LMNAF2TAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-A1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | Elan Pharmaceuticals, Inc. (US) | 2006-03-15 | — | — | EP | claimed |
| WO-2004098589-A1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARMACEUTICALS, INC. (US) | 2004-11-18 | — | — | WO | claimed |