Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 17/20 | 0.77 |
| ▸ | MMP2 | P08253 | 3/20 | 0.56 |
| ▸ | MMP14 | P50281 | 2/20 | 0.56 |
| ▸ | MMP13 | P45452 | 10/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.52 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789356 | 0.93 | ADAMTS4 (0.66) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL8284829 | 0.87 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL1656897 | 0.87 | ADAMTS4 (1.00) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL3612160 | 0.86 | ADAMTS4 (0.78) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL13314513 | 0.86 | ADAMTS4 (0.78) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL3603941 | 0.79 | ADAMTS4 (0.67) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL1656276 | 0.78 | ADAMTS4 (0.79) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL27667449 | 0.78 | ADAMTS4 (0.79) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL27667450 | 0.76 | ADAMTS4 (0.73) | ADAMTS4MMP2MMP14MMP13ADAMTS5 | |
| SCHEMBL8284856 | 0.73 | ADAMTS4 (0.76) | ADAMTS4MMP2MMP14MMP13ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692124-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | Wyeth (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005061477-A1 | BIARYL SULFONAMIDES AS MMP INHIBITORS | WYETH (US) | 2005-07-07 | — | — | WO | claimed |