Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 2/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352623 | 0.86 | TTK (0.35) | PDPK1JAK2GRM4GSK3BTYK2 | |
| SCHEMBL130781 | 0.80 | ITK (0.47) | PDE3BPDE3A | |
| SCHEMBL10189221 | 0.80 | KIF11 (0.47) | PDE3BPDE3AFGFR1GRM4GSK3B | |
| SCHEMBL11388 | 0.79 | PDPK1 (0.58) | PDE3BPDE3APDPK1JAK2GSK3B | |
| SCHEMBL176792 | 0.79 | PDPK1 (0.54) | FGFR1PDPK1JAK2GSK3BJAK1 | |
| SCHEMBL16095565 | 0.79 | AXL (0.50) | PDE3BPDE3AFGFR1PDPK1JAK2 | |
| SCHEMBL5677771 | 0.79 | MAP2K4 (0.51) | GSK3B | |
| SCHEMBL10271450 | 0.79 | GSK3B (0.51) | GSK3B | |
| SCHEMBL5677761 | 0.77 | GSK3B (0.44) | PDE3BPDE3AFGFR1PDPK1JAK2 | |
| Hydrochloric Acid SCHEMBL177126 | 0.77 | PDPK1 (0.53) | FGFR1PDPK1JAK2GSK3BJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |