Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 7/20 | 0.42 |
| ▸ | JAK1 | P23458 | 7/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL579033 | 1.00 | SYK (0.51) | SYKPTK2BRD4IGF1RJAK2 | |
| SCHEMBL578928 | 0.92 | AURKA (0.53) | SYKPTK2IGF1RJAK2JAK1 | |
| SCHEMBL578750 | 0.92 | SYK (0.50) | SYKPTK2JAK2JAK1AURKB | |
| SCHEMBL578929 | 0.92 | AURKA (0.53) | SYKPTK2IGF1RJAK2JAK1 | |
| SCHEMBL578749 | 0.92 | SYK (0.50) | SYKPTK2JAK2JAK1AURKB | |
| SCHEMBL578672 | 0.90 | PTK2 (0.57) | SYKPTK2IGF1RAURKAJAK3 | |
| SCHEMBL12174633 | 0.90 | PTK2 (0.57) | SYKPTK2IGF1RAURKAJAK3 | |
| SCHEMBL578671 | 0.90 | PTK2 (0.57) | SYKPTK2IGF1RAURKAJAK3 | |
| SCHEMBL578714 | 0.90 | PTK2 (0.57) | SYKPTK2IGF1RAURKAJAK3 | |
| SCHEMBL13808220 | 0.89 | PTK2 (0.55) | SYKPTK2IGF1RAURKAJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027107-B1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-02-15 | — | — | EP | claimed |
| EP-2027107-B1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-02-15 | — | — | EP | disclosed |