Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3154235 | 0.94 | POLB (0.63) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL13450089 | 0.94 | POLB (0.63) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL24636855 | 0.93 | POLB (0.66) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL19750331 | 0.92 | MEN1 (0.64) | POLBKMT2AMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4711057 | 0.91 | POLB (0.60) | POLBKMT2AMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4711056 | 0.91 | POLB (0.60) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL3157460 | 0.89 | POLB (0.61) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1190641 | 0.89 | POLB (0.61) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL3560864 | 0.89 | POLB (0.61) | POLBKMT2AMEN1NPC1RAB9A | |
| SCHEMBL19565932 | 0.88 | POLB (0.57) | POLBKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1867549-B | Cyclopropyl derivatives as NK3 receptor antagonists | LUNDBECK & CO AS H | 2011-07-06 | — | — | CN | disclosed |
| WO-2005016884-A9 | CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2006-03-16 | — | — | WO | disclosed |