Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24636855 | 0.95 | POLB (0.66) | MEN1KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL5790489 | 0.92 | POLB (0.69) | MEN1KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL3154235 | 0.86 | POLB (0.63) | MEN1KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL13450089 | 0.86 | POLB (0.63) | MEN1KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL26522945 | 0.84 | KMT2A (0.50) | MEN1KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL3560864 | 0.84 | POLB (0.61) | MEN1KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL1190641 | 0.84 | POLB (0.61) | MEN1KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL3157460 | 0.84 | POLB (0.61) | MEN1KMT2APOLBHTTSMN1; SMN2 | |
| SCHEMBL28694741 | 0.83 | MEN1 (0.73) | MEN1KMT2AHTTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL4713610 | 0.83 | POLB (0.60) | MEN1KMT2APOLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850276-B2 | Bidentate-binding modulators of LRRK2 and JNK kinases | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-12-26 | — | — | US | disclosed |