Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367885 | 1.00 | KDR (0.66) | KDREPHA2EPHB4ERBB2KIT | |
| SCHEMBL5792275 | 0.91 | KDR (0.66) | KDRKITPDGFRALCKCSF1R | |
| SCHEMBL4367202 | 0.91 | KDR (0.66) | KDRKITPDGFRALCKCSF1R | |
| SCHEMBL4368117 | 0.84 | KDR (0.51) | KDRKITPDGFRARAF1BRAF | |
| SCHEMBL4362218 | 0.82 | KDR (0.58) | KDRKITLCKCSF1RIGF1R | |
| SCHEMBL5788446 | 0.82 | KDR (0.53) | KDRKITLCKCSF1RIGF1R | |
| SCHEMBL5790847 | 0.82 | KDR (0.53) | KDRKITLCKCSF1RIGF1R | |
| SCHEMBL4364753 | 0.81 | KDR (0.49) | KDRKITLCKCSF1RIGF1R | |
| SCHEMBL4369696 | 0.80 | KDR (1.00) | KDREPHA2EPHB4ERBB2KIT | |
| SCHEMBL4367877 | 0.80 | KDR (1.00) | KDREPHA2EPHB4ERBB2KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638954-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004085425-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC (US) | 2004-10-07 | — | — | WO | disclosed |