Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | METAP2 | P50579 | 2/20 | 0.54 |
| ▸ | METAP1 | P53582 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30013579 | 0.98 | POLB (0.61) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL1043186 | 0.98 | POLB (0.61) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL5790837 | 0.97 | POLB (0.60) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL5792452 | 0.84 | POLB (0.59) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL5790838 | 0.84 | POLB (0.56) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL5792686 | 0.84 | POLB (0.59) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL15818865 | 0.84 | POLB (0.59) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL15820245 | 0.82 | POLB (0.54) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL9284195 | 0.81 | LMNA (0.55) | POLBLMNAMETAP2METAP1HDAC6 | |
| SCHEMBL1101672 | 0.79 | MEN1 (0.72) | POLBLMNAMETAP2METAP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663234-A1 | PIPERAZINE DERIVATIVES FOR THE TREATMENT OF HIV INFECTIONS | Pfizer Limited (GB) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005016344-A1 | PIPERAZINE DERIVATIVES FOR THE TREATMENT OF HIV INFECTIONS | PFIZER LIMITED (GB) | 2005-02-24 | — | — | WO | disclosed |