Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 11/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.49 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990072 | 0.95 | APP (0.89) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL3936259 | 0.95 | APP (0.90) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1373512 | 0.90 | APP (1.00) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL3942347 | 0.86 | APP (0.92) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1371389 | 0.80 | APP (0.80) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1374640 | 0.78 | APP (0.79) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1371930 | 0.77 | APP (0.82) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1374496 | 0.77 | APP (1.00) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1371328 | 0.75 | CYP3A4 (0.79) | APPCYP2C9CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL1373499 | 0.73 | APP (1.00) | APPCYP2C9CYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006020850-A2 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| WO-2006020852-A2 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| WO-2006020853-A2 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |