Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 12/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 7/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 6/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.56 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.53 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.53 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.53 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.53 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.53 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5479423 | 0.91 | APP (0.84) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1374640 | 0.88 | APP (0.79) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1371389 | 0.84 | APP (0.80) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1373512 | 0.82 | APP (1.00) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1374496 | 0.80 | APP (1.00) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL3942347 | 0.78 | APP (0.92) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL3936259 | 0.78 | APP (0.90) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1371367 | 0.78 | APP (0.65) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL4990072 | 0.77 | APP (0.89) | APPCYP2C9CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL1374499 | 0.76 | APP (0.71) | APPCYP2C9CYP2C19CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080033045-A1 | TREATMENT OF PSYCHIATRIC DISORDERS | MYRIAD GENETICS, INCORPORATED (US) | 2008-02-07 | — | — | US | claimed |
| US-20070232589-A1 | Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders | MYRIAD GENETICS, INCORPORATED (US) | 2007-10-04 | — | — | US | claimed |
| US-20070232656-A1 | Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders | MYRIAD GENETICS, INCORPORATED (US) | 2007-10-04 | — | — | US | claimed |
| US-20070232672-A1 | Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders | MYRIAD GENETICS, INCORPORATED (US) | 2007-10-04 | — | — | US | claimed |
| US-20070015832-A1 | Methods of treating overactive bladder and urinary incontinence | MYRIAD GENETICS, INCORPORATED (US) | 2007-01-18 | — | — | US | claimed |
| WO-2006020850-A2 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2006-02-23 | — | — | WO | claimed |
| WO-2006020852-A2 | PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS | MYRIAD GENETICS, INC. (US) | 2006-02-23 | — | — | WO | claimed |
| US-9592210-B2 | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-03-14 | — | — | US | disclosed |
| WO-2015173133-A1 | FORMULATIONS AND METHODS OF TREATING ALZHEIMER'S DISEASE AND OTHER PROTEINOPATHIES BY COMBINATION THERAPY | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-11-19 | — | — | WO | disclosed |
| US-20150320706-A1 | FORMULATIONS AND METHODS OF TREATING ALZHEIMER'S DISEASE AND OTHER PROTEINOPATHIES BY COMBINATION THERAPY | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-11-12 | — | — | US | disclosed |
| US-20150065567-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND MULTIPLE SCLEROSIS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-03-05 | — | — | US | disclosed |
| US-20130165505-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-06-27 | — | — | US | disclosed |
| US-8314268-B2 | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-11-20 | — | — | US | disclosed |
| US-20080033045-A1 | TREATMENT OF PSYCHIATRIC DISORDERS | MYRIAD GENETICS, INCORPORATED (US) | 2008-02-07 | — | — | US | disclosed |
| US-20070293538-A1 | Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders | MYRIAD GENETICS, INCORPORATED (US) | 2007-12-20 | — | — | US | disclosed |
| US-20070232589-A1 | Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders | MYRIAD GENETICS, INCORPORATED (US) | 2007-10-04 | — | — | US | disclosed |
| US-20070232672-A1 | Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders | MYRIAD GENETICS, INCORPORATED (US) | 2007-10-04 | — | — | US | disclosed |
| US-20070078114-A1 | COMBINATION THERAPY FOR ALZHEIMER'S DISEASE AND OTHER DISEASES | MYRIAD GENETICS, INCORPORATED (US) | 2007-04-05 | — | — | US | disclosed |
| US-20070060752-A1 | 1-(2-Fluoro-4'-trifluoromethylbiphenyl-4-yl)cyclopropanecarboxylic acid, for example; treatment and/or prevention of Alzheimer's disease; inhibiting the release of A beta 42 peptide thereby being able to modulate gamma-secretase activity without affecting other important metabolic processes | CHIESI FARMACEUTICI S.P.A. (IT) | 2007-03-15 | — | — | US | disclosed |
| US-20070015832-A1 | Methods of treating overactive bladder and urinary incontinence | MYRIAD GENETICS, INCORPORATED (US) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015832-A1 | Methods of treating overactive bladder and urinary incontinence | MME, AVPR1B, AVPR2 | APP 2522/4885CYP2C9 3765/4885CYP2C19 2701/4885 |
| US-20070232672-A1 | Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders | ACHE, BCHE, CHAT | APP 21/4885CYP2C9 1035/4885CYP2C19 540/4885 |
| US-20070232589-A1 | Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders | ACHE, BCHE, CHAT | APP 29/4885CYP2C9 1156/4885CYP2C19 630/4885 |
| US-20130165505-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT | PSEN1, PSEN2, NAT1 | APP 15/4885CYP2C9 1978/4885CYP2C19 1159/4885 |
| US-20150320706-A1 | FORMULATIONS AND METHODS OF TREATING ALZHEIMER'S DISEASE AND OTHER PROTEINOPATHIES BY COMBINATION THERAPY | MAPT, GABRA5, MAP1LC3A | APP 6/4885CYP2C9 4477/4885CYP2C19 4354/4885 |
| US-20070078114-A1 | COMBINATION THERAPY FOR ALZHEIMER'S DISEASE AND OTHER DISEASES | PSEN2, APP, PSEN1 | APP 2/4885CYP2C9 4757/4885CYP2C19 4045/4885 |
| US-20070060752-A1 | 1-(2-Fluoro-4'-trifluoromethylbiphenyl-4-yl)cyclopropanecarboxylic acid, for example; treatment and/or prevention of Alzheimer's disease; inhibiting the release of A beta 42 peptide thereby being able to modulate gamma-secretase activity without affecting other important metabolic processes | BACE1, APP, BACE2 | APP 2/4885CYP2C9 1801/4885CYP2C19 1262/4885 |
| US-20070293538-A1 | Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders | GRN, NLN, PSEN1 | APP 9/4885CYP2C9 556/4885CYP2C19 235/4885 |
| US-20150065567-A1 | 1-PHENYLALKANECARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND MULTIPLE SCLEROSIS | PSEN1, APP, PSEN2 | APP 2/4885CYP2C9 3448/4885CYP2C19 3534/4885 |
| US-20070232656-A1 | Pharmaceutical Composition And Method For Treating Neurodegenerative Disorders | ACHE, BCHE, CHAT | APP 21/4885CYP2C9 1035/4885CYP2C19 540/4885 |
| US-20080033045-A1 | TREATMENT OF PSYCHIATRIC DISORDERS | SLC6A3, SLC6A2, FKBP5 | APP 2500/4885CYP2C9 2722/4885CYP2C19 1083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.