Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.40 |
| ▸ | RAB9A | P51151 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599408 | 0.92 | CRHR1 (0.40) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL5791329 | 0.89 | CRHR1 (0.39) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL5785419 | 0.81 | CRHR1 (0.35) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL27517037 | 0.80 | MEN1 (0.41) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL5787115 | 0.80 | CRHR1 (0.36) | KMT2AMEN1CRHR1 | |
| SCHEMBL5791018 | 0.76 | CRHR1 (0.60) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL5790778 | 0.72 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL5785875 | 0.71 | CRHR1 (0.41) | KMT2AMEN1CRHR1 | |
| SCHEMBL5599886 | 0.71 | NPY1R (0.51) | CRHR1TSHR | |
| SCHEMBL5787088 | 0.70 | CRHR1 (0.40) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923582-B1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER (US) | 2006-09-20 | — | — | EP | disclosed |
| US-6900217-B2 | Substituted 6,5-hetero-bicyclic derivatives | PFIZER INC (US) | 2005-05-31 | — | — | US | disclosed |
| US-20050009823-A1 | Substituted 6,5-hetero-bicyclic derivatives | PFIZER INC | 2005-01-13 | — | — | US | disclosed |
| US-20020151713-A1 | Substituted 6,5-hetero-bicyclic derivatives | PFIZER INC. | 2002-10-17 | — | — | US | disclosed |
| US-20010007867-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | CHEN YUHPYNG L (US) | 2001-07-12 | — | — | US | disclosed |
| EP-0923582-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008847-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | PFIZER INC. (US) | 1998-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009823-A1 | Substituted 6,5-hetero-bicyclic derivatives | CYP2D6, CYP2B6, ABCG2 | MAPT 2866/4885RAB9A 949/4885KDM4E 895/4885 |
| US-20020151713-A1 | Substituted 6,5-hetero-bicyclic derivatives | CYP2D6, CYP2B6, CYP3A5 | MAPT 2284/4885RAB9A 428/4885KDM4E 541/4885 |
| US-20010007867-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | CYP2D6, CYP2B6, CYP3A5 | MAPT 3698/4885RAB9A 406/4885KDM4E 836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.