Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12889682 | 1.00 | LMNA (0.38) | LMNAMAPK1HTTCYP2C9POLB | |
| SCHEMBL7524665 | 0.86 | HTT (0.46) | LMNAMAPK1HTTCYP2C9POLB | |
| SCHEMBL12889684 | 0.82 | LMNA (0.37) | LMNAMAPK1HTTCYP2C9POLB | |
| SCHEMBL21321660 | 0.81 | HTT (0.41) | LMNAMAPK1HTTCYP2C9POLB | |
| SCHEMBL3363288 | 0.79 | — | — | |
| SCHEMBL12889696 | 0.77 | TLR4 (0.35) | LMNAMAPK1HTTCYP2C9 | |
| SCHEMBL9061860 | 0.77 | LMNA (0.39) | LMNAMAPK1HTTCYP2C9POLB | |
| SCHEMBL8218872 | 0.76 | HTT (0.40) | LMNAMAPK1HTTCYP2C9POLB | |
| SCHEMBL12889693 | 0.76 | LMNA (0.33) | LMNAMAPK1HTTKMT2AALDH1A1 | |
| Methyl Alcohol SCHEMBL27749194 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482019-B1 | Pyran derivatives | MERCK PATENT GMBH (DE) | 2006-09-27 | — | — | EP | disclosed |
| EP-1482019-A1 | Pyran derivatives | MERCK PATENT GmbH (DE) | 2004-12-01 | — | — | EP | disclosed |