Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462238 | 0.96 | BRAF (0.41) | BRAFPPARGHDAC1HDAC8HDAC6 | |
| SCHEMBL5791013 | 0.93 | BRAF (0.39) | BRAFPPARGHDAC1HDAC8HDAC6 | |
| SCHEMBL1379069 | 0.85 | BRAF (0.39) | BRAFHDAC1HDAC8HDAC6GPR142 | |
| SCHEMBL4463265 | 0.82 | BRAF (0.41) | BRAFPPARGPPARANR1H4GPR142 | |
| SCHEMBL4508137 | 0.82 | MEN1 (0.50) | BRAFPPARGHDAC1HDAC8HDAC6 | |
| Pivalamide SCHEMBL5794562 | 0.81 | NR1H4 (0.37) | BRAFPPARGNR1H4GPR142 | |
| SCHEMBL1414199 | 0.81 | BRAF (0.41) | BRAFPPARGPPARANR1H4GPR142 | |
| SCHEMBL4473152 | 0.80 | BRAF (0.44) | BRAFGPR142 | |
| Pivalamide SCHEMBL6807091 | 0.80 | BRAF (0.49) | BRAF | |
| SCHEMBL5794885 | 0.79 | BRAF (0.39) | BRAFPPARGNR1H4GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692116-A1 | 1,2,3-TRIAZOLE AMIDE DERIVATIVES AS INHIBITORS OF CYTOKINE PRODUCTION | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056535-A1 | 1,2,3-TRIAZOLE AMIDE DERIVATIVES AS INHIBITORS OF CYTOKINE PRODUCTION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-06-23 | — | — | WO | disclosed |