Sugi Predict

Sugi Predict / Compounds / Pivalamide

Pivalamide

Pivalamide

SCHEMBL6807091

CC(C)(C)C(N)=O.COc1c(NC(=O)c2ccc(C)c(-n3cc(C(=O)O)nn3)c2)cc(C(C)(C)C)cc1NS(C)(=O)=O

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 18/20 0.49
▸ MAPK14 Q16539 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4495780 0.96 BRAF (0.52) BRAFMAPK14
SCHEMBL6807095 0.93 BRAF (0.48) BRAFMAPK14
SCHEMBL6194179 0.93 BRAF (0.49) BRAFMAPK14
SCHEMBL4487673 0.92 BRAF (0.51) BRAFMAPK14
Niacinamide SCHEMBL6808229 0.90 BRAF (0.45) BRAFMAPK14
SCHEMBL4490549 0.90 BRAF (0.52) BRAFMAPK14
SCHEMBL4490603 0.89 BRAF (0.51) BRAFMAPK14
SCHEMBL4487218 0.89 BRAF (0.51) BRAFMAPK14
SCHEMBL5621750 0.89 BRAF (0.48) BRAF
SCHEMBL4483034 0.89 BRAF (0.49) BRAFMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040102492-A1 Cytokine inhibitors BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. 2004-05-27 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040102492-A1 Cytokine inhibitors IL1A, IL1B, IL1RN BRAF 3740/4885MAPK14 1621/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.