Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837879 | 1.00 | NPSR1 (0.43) | NPSR1LMNAHTTALDH1A1SLC18A3 | |
| SCHEMBL4833881 | 1.00 | NPSR1 (0.43) | NPSR1LMNAHTTALDH1A1SLC18A3 | |
| SCHEMBL4839855 | 0.78 | NPSR1 (0.42) | NPSR1LMNAHTTALDH1A1CASP3 | |
| SCHEMBL4837823 | 0.78 | NPSR1 (0.42) | NPSR1LMNAHTTALDH1A1CASP3 | |
| SCHEMBL4841214 | 0.77 | TSHR (0.38) | LMNAALDH1A1KMT2AGAA | |
| SCHEMBL4841772 | 0.77 | TSHR (0.38) | LMNAALDH1A1KMT2AGAA | |
| SCHEMBL4834022 | 0.74 | GRM2 (0.33) | LMNA | |
| SCHEMBL4834368 | 0.74 | GRM2 (0.33) | LMNA | |
| SCHEMBL4839870 | 0.72 | ALDH1A1 (0.44) | NPSR1HTTALDH1A1MEN1KMT2A | |
| SCHEMBL5791105 | 0.72 | ALDH1A1 (0.44) | NPSR1HTTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |