Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | PLG | P00747 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8958702 | 0.67 | CHRM5 (0.36) | MAOAMAOB | |
| SCHEMBL11768638 | 0.66 | CYP2D6 (0.40) | HTR3AMAOAMAOBHTR2A | |
| SCHEMBL18945784 | 0.64 | HTR3A (0.39) | HTR3AHTR2AHTR2C | |
| SCHEMBL27307555 | 0.62 | HTR3A (0.37) | HTR3AHTR2AHTR2C | |
| SCHEMBL18945740 | 0.61 | HTR2A (0.39) | HTR3AHTR2AHTR2C | |
| SCHEMBL16874832 | 0.60 | MAPT (0.39) | MAPTTHRBGABRA1GABRG2GABRB3 | |
| SCHEMBL23706644 | 0.59 | — | — | |
| SCHEMBL495695 | 0.57 | SLC18A3 (0.75) | HTR3AJAK3 | |
| SCHEMBL495697 | 0.57 | SLC18A3 (0.75) | HTR3AJAK3 | |
| SCHEMBL4122 | 0.57 | SLC18A3 (0.75) | HTR3AJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-B1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2020-03-18 | — | — | EP | disclosed |
| EP-1242400-B1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORP (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| EP-0720600-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008534-A1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO WELLCOME INC. (US) | 1995-03-30 | — | — | WO | disclosed |