Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.55 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796002 | 0.94 | EGFR (0.54) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL5795899 | 0.94 | EGFR (0.63) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL5793460 | 0.94 | EGFR (0.54) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL5792742 | 0.92 | EGFR (0.62) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL5792777 | 0.86 | EGFR (0.61) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL5795480 | 0.86 | EGFR (0.61) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL7099826 | 0.84 | EGFR (0.66) | EGFRERBB2 | |
| SCHEMBL5795760 | 0.84 | EGFR (0.57) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL5765643 | 0.81 | EGFR (0.72) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL7095294 | 0.81 | ERBB2 (0.60) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460072-B1 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | GLAXO GROUP LTD (GB) | 2006-04-05 | — | — | EP | claimed |