Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 15/20 | 0.60 |
| ▸ | EGFR | P00533 | 13/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099826 | 0.96 | EGFR (0.66) | ERBB2EGFR | |
| SCHEMBL5792742 | 0.89 | EGFR (0.62) | ERBB2EGFR | |
| SCHEMBL7093321 | 0.87 | ERBB2 (0.51) | ERBB2EGFR | |
| SCHEMBL5792777 | 0.86 | EGFR (0.61) | ERBB2EGFR | |
| SCHEMBL5796002 | 0.86 | EGFR (0.54) | ERBB2EGFR | |
| SCHEMBL5795480 | 0.86 | EGFR (0.61) | ERBB2EGFR | |
| SCHEMBL7149274 | 0.86 | ERBB2 (0.60) | ERBB2EGFR | |
| SCHEMBL5792052 | 0.81 | EGFR (0.55) | ERBB2EGFR | |
| SCHEMBL7009047 | 0.80 | ERBB2 (0.91) | ERBB2EGFR | |
| SCHEMBL5793460 | 0.80 | EGFR (0.54) | ERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912572-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2003-01-15 | — | — | EP | claimed |