Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | BCL3 | P20749 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7809769 | 0.88 | MAPK14 (0.61) | MAPK14EPHX2PARP1POLBSIGMAR1 | |
| SCHEMBL5323843 | 0.84 | MAPK14 (0.56) | MAPK14KMT2AEPHX2PARP1FFAR1 | |
| SCHEMBL1384090 | 0.76 | MAPK14 (0.80) | MAPK14 | |
| SCHEMBL5322574 | 0.74 | MAPK14 (0.61) | MAPK14EPHX2PARP1POLBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL7468024 | 0.73 | MAPK14 (0.60) | MAPK14EPHX2PARP1POLBSIGMAR1 | |
| SCHEMBL7475922 | 0.73 | MAPK14 (0.44) | MAPK14KMT2ADRD2SLC6A4SLC6A3 | |
| SCHEMBL1385480 | 0.72 | MAPK14 (1.00) | MAPK14 | |
| Hydrochloric Acid SCHEMBL7812345 | 0.72 | MAPK14 (0.62) | MAPK14EPHX2 | |
| Hydrochloric Acid SCHEMBL6157505 | 0.72 | MAPK14 (0.98) | MAPK14 | |
| Hydrochloric Acid SCHEMBL7809765 | 0.70 | MAPK14 (0.67) | MAPK14EPHX2POLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641764-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | Novartis AG (CH) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005009973-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2005-02-03 | — | — | WO | disclosed |