Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323843 | 0.89 | MAPK14 (0.56) | MAPK14SLC6A4DRD2SLC6A3KIF11 | |
| SCHEMBL7803286 | 0.81 | MAPK14 (0.54) | MAPK14SLC6A4DRD2SLC6A3SIGMAR1 | |
| SCHEMBL7475964 | 0.80 | CYP2D6 (0.47) | ALOX15GAAALDH1A1HTTLMNA | |
| SCHEMBL7482460 | 0.79 | MAPK14 (0.53) | MAPK14ALOX15MAPK8MAPK10 | |
| SCHEMBL5322574 | 0.78 | MAPK14 (0.61) | MAPK14GAASIGMAR1ALDH1A1LMNA | |
| SCHEMBL7481210 | 0.77 | PTAFR (0.42) | MAPK14ALOX15ALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL7468024 | 0.77 | MAPK14 (0.60) | MAPK14SIGMAR1 | |
| SCHEMBL6160299 | 0.75 | MAPK14 (0.64) | MAPK14 | |
| SCHEMBL7464576 | 0.73 | ALOX15 (0.47) | MAPK14ALOX15KMT2AMAPK10 | |
| SCHEMBL7474793 | 0.73 | ALOX15 (0.44) | MAPK14ALOX15GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |