Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 16/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL447746 | 1.00 | P2RY12 (0.40) | P2RY12HDAC3APPACHEHDAC4 | |
| SCHEMBL445438 | 0.86 | P2RY12 (0.51) | P2RY12 | |
| SCHEMBL4033149 | 0.85 | P2RY12 (0.39) | P2RY12 | |
| SCHEMBL447747 | 0.85 | HDAC3 (0.40) | P2RY12HDAC3APPACHEHDAC4 | |
| SCHEMBL446790 | 0.84 | P2RY12 (0.41) | P2RY12HDAC3APPACHEHDAC4 | |
| SCHEMBL446789 | 0.84 | P2RY12 (0.41) | P2RY12HDAC3APPACHEHDAC4 | |
| SCHEMBL445820 | 0.81 | MAPT (0.46) | P2RY12HDAC3APPACHEHDAC4 | |
| SCHEMBL447748 | 0.79 | HDAC6 (0.42) | P2RY12HDAC3APPACHEHDAC4 | |
| SCHEMBL4255470 | 0.78 | P2RY12 (0.39) | P2RY12HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4247839 | 0.77 | P2RY12 (0.40) | P2RY12EPHX2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611088-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | claimed |
| WO-2004092115-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS INC. (US) | 2004-10-28 | — | — | WO | claimed |