Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1168527 | 1.00 | TP53 (0.48) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL3191804 | 0.87 | CYP2D6 (0.47) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL1169343 | 0.87 | CYP2D6 (0.47) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL8300221 | 0.81 | PSEN1 (0.47) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL1168928 | 0.80 | TP53 (0.47) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL1168925 | 0.80 | TP53 (0.47) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL7136404 | 0.80 | SLC1A3 (0.48) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL1168929 | 0.80 | TP53 (0.47) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL2886972 | 0.78 | PSEN1 (0.62) | TP53SMN1; SMN2ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL13404723 | 0.78 | PSEN1 (0.46) | TP53SMN1; SMN2ALDH1A1CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-B1 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2006-06-21 | — | — | EP | disclosed |