Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3191804 | 0.89 | CYP2D6 (0.47) | SLC1A3SLC1A2SLC1A1CYP2D6CYP2C9 | |
| SCHEMBL1169343 | 0.89 | CYP2D6 (0.47) | SLC1A3SLC1A2SLC1A1CYP2D6CYP2C9 | |
| SCHEMBL1168527 | 0.80 | TP53 (0.48) | SLC1A3SLC1A2SLC1A1CYP2D6CYP2C9 | |
| SCHEMBL5793447 | 0.80 | TP53 (0.48) | SLC1A3SLC1A2SLC1A1CYP2D6CYP2C9 | |
| SCHEMBL6988608 | 0.77 | PSEN1 (0.56) | SMN1; SMN2ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL8300221 | 0.72 | PSEN1 (0.47) | SLC1A3SLC1A2SLC1A1CYP2D6CYP2C9 | |
| SCHEMBL2886972 | 0.71 | PSEN1 (0.62) | SLC1A3SLC1A2SLC1A1CYP2D6CYP2C9 | |
| SCHEMBL5654675 | 0.71 | PSEN1 (0.62) | SLC1A3SLC1A2SLC1A1CYP2D6CYP2C9 | |
| SCHEMBL7202062 | 0.71 | CYP2C9 (0.50) | CYP2D6CYP2C9CYP2C19TP53ALDH1A1 | |
| SCHEMBL7915450 | 0.71 | CYP2D6 (0.56) | SLC1A3SLC1A2SLC1A1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | disclosed |