Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796566 | 1.00 | MAPT (0.46) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5793348 | 0.94 | MAPT (0.48) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5796795 | 0.92 | MAPT (0.45) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5794585 | 0.89 | SMN1; SMN2 (0.44) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5794961 | 0.87 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5796898 | 0.84 | UTS2R (0.42) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5806244 | 0.84 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5793771 | 0.82 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5795178 | 0.82 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5796674 | 0.79 | MAPT (0.39) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006015279-A1 | HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS | NEUROGEN CORPORATION (US) | 2006-02-09 | — | — | WO | claimed |
| WO-2006015279-A1 | HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS | NEUROGEN CORPORATION (US) | 2006-02-09 | — | — | WO | disclosed |