Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5796637 | 0.89 | LMNA (0.59) | SMN1; SMN2MAPTNPSR1CRHBPCRHR2 | |
| SCHEMBL5793764 | 0.82 | MAPT (0.46) | SMN1; SMN2MAPTCRHBPCRHR2ALDH1A1 | |
| SCHEMBL5796566 | 0.82 | MAPT (0.46) | SMN1; SMN2MAPTCRHBPCRHR2ALDH1A1 | |
| SCHEMBL5820332 | 0.81 | LMNA (0.54) | SMN1; SMN2MAPTNPSR1CRHBPCRHR2 | |
| SCHEMBL5793348 | 0.76 | MAPT (0.48) | SMN1; SMN2MAPTCRHBPCRHR2ALDH1A1 | |
| SCHEMBL5794482 | 0.75 | MAPT (0.56) | SMN1; SMN2MAPTNPSR1ALDH1A1KMT2A | |
| SCHEMBL5796795 | 0.74 | MAPT (0.45) | SMN1; SMN2MAPTCRHBPCRHR2ALDH1A1 | |
| SCHEMBL12125064 | 0.73 | MAPK1 (0.53) | SMN1; SMN2MAPTCRHBPCRHR2ALDH1A1 | |
| SCHEMBL5796674 | 0.73 | MAPT (0.39) | SMN1; SMN2MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL5794095 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTNPSR1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006015279-A1 | HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS | NEUROGEN CORPORATION (US) | 2006-02-09 | — | — | WO | claimed |
| WO-2006015279-A1 | HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS | NEUROGEN CORPORATION (US) | 2006-02-09 | — | — | WO | disclosed |