Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794891 | 0.90 | IGF1R (0.50) | IGF1RCDK2RETGSK3BPRKCA | |
| SCHEMBL5793291 | 0.88 | IGF1R (0.56) | IGF1RCDK2RETGSK3BPRKCA | |
| SCHEMBL5798073 | 0.84 | IGF1R (0.45) | IGF1RRETAURKAKDRFLT4 | |
| SCHEMBL5796367 | 0.83 | BRD4 (0.45) | IGF1RKDRFLT4 | |
| SCHEMBL5818753 | 0.80 | IGF1R (0.47) | IGF1RCDK2GSK3BPRKCAMAPT | |
| SCHEMBL1748786 | 0.79 | IGF1R (0.83) | IGF1RCDK2RETGSK3BAURKB | |
| SCHEMBL5794484 | 0.77 | IGF1R (0.40) | IGF1RGSK3BMEN1ALDH1A1MAPT | |
| SCHEMBL5794829 | 0.73 | IGF1R (0.39) | IGF1RCDK2GSK3BMEN1ALDH1A1 | |
| SCHEMBL5070003 | 0.72 | GSK3B (0.56) | IGF1RRETGSK3BPRKCAMEN1 | |
| SCHEMBL5795129 | 0.70 | GSK3B (0.42) | IGF1RCDK2GSK3BKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732546-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095399-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |