Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | CIT | O14578 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794201 | 0.90 | IGF1R (0.49) | IGF1RKDRGSK3BAURKBJAK2 | |
| SCHEMBL5793291 | 0.89 | IGF1R (0.56) | IGF1RKDRGSK3BAURKBJAK2 | |
| SCHEMBL5798073 | 0.85 | IGF1R (0.45) | IGF1RKDRFGFR1FLT1AURKA | |
| SCHEMBL5796367 | 0.84 | BRD4 (0.45) | IGF1RKDRFGFR1FLT1 | |
| SCHEMBL5794484 | 0.82 | IGF1R (0.40) | IGF1RGSK3BDYRK1A | |
| SCHEMBL5818753 | 0.81 | IGF1R (0.47) | IGF1RKDRGSK3BAURKBJAK2 | |
| SCHEMBL1749198 | 0.78 | IGF1R (0.84) | IGF1RKDRGSK3BAURKBJAK2 | |
| SCHEMBL5794829 | 0.74 | IGF1R (0.39) | IGF1RKDRGSK3BFLT3CDK2 | |
| SCHEMBL5070003 | 0.73 | GSK3B (0.56) | IGF1RGSK3BAURKBJAK2LCK | |
| SCHEMBL5795129 | 0.71 | GSK3B (0.42) | IGF1RKDRGSK3BFLT3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732546-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095399-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |