Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268803 | 0.93 | FGFR4 (0.36) | CTSKCTSLCTSBFGFR4CTSS | |
| Trifluoroacetic Acid SCHEMBL5794377 | 0.91 | CTSK (0.42) | CTSKCTSLCTSBFGFR4CTSS | |
| SCHEMBL8268800 | 0.86 | FGFR4 (0.37) | CTSKCTSLCTSBFGFR4CTSS | |
| SCHEMBL8268798 | 0.86 | CTSK (0.43) | CTSKCTSLCTSBFGFR4CTSS | |
| SCHEMBL5791902 | 0.84 | FGFR4 (0.38) | CTSKCTSLCTSBFGFR4CTSS | |
| Trifluoroacetic Acid SCHEMBL5791713 | 0.84 | CTSK (0.37) | CTSKCTSLCTSBFGFR4CTSS | |
| Trifluoroacetic Acid SCHEMBL5794345 | 0.84 | CTSK (0.38) | CTSKCTSLCTSBFGFR4CTSS | |
| SCHEMBL5794206 | 0.84 | FGFR4 (0.35) | CTSKCTSLCTSBFGFR4CTSS | |
| Trifluoroacetic Acid SCHEMBL5791379 | 0.83 | CTSK (0.38) | CTSKCTSLCTSBFGFR4CTSS | |
| SCHEMBL8270003 | 0.82 | CTSK (0.39) | CTSKCTSLCTSBFGFR4CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |