Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 15/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794394 | 0.81 | KDM1A (0.41) | XIAPNAMPTACE | |
| SCHEMBL5793583 | 0.81 | XIAP (0.47) | XIAPTAAR1HDAC1HDAC2HDAC8 | |
| SCHEMBL5791866 | 0.78 | TAAR1 (0.43) | XIAPTAAR1 | |
| SCHEMBL4833456 | 0.77 | PSEN1 (0.51) | XIAP | |
| SCHEMBL5795407 | 0.77 | XIAP (0.46) | XIAPTAAR1 | |
| SCHEMBL5794323 | 0.77 | XIAP (0.46) | XIAPTAAR1 | |
| SCHEMBL4834377 | 0.77 | PSEN1 (0.55) | — | |
| Hydrochloric Acid SCHEMBL25345671 | 0.75 | XIAP (0.53) | XIAPMMEACE | |
| Hydrochloric Acid SCHEMBL25345659 | 0.75 | XIAP (0.53) | XIAPMMEACE | |
| Hydrochloric Acid SCHEMBL25345665 | 0.75 | XIAP (0.53) | XIAPMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |