Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320768 | 0.78 | ACHE (0.48) | TLR8LMNAKDM4ETP53CYP3A4 | |
| SCHEMBL3354950 | 0.78 | TLR8 (0.38) | PRMT5TLR8TLR7LMNAHRH4 | |
| SCHEMBL6053091 | 0.78 | TLR8 (0.38) | PRMT5TLR8TLR7LMNAHRH4 | |
| SCHEMBL3351060 | 0.78 | TLR8 (0.44) | PRMT5TLR8TLR7HTT | |
| SCHEMBL5350898 | 0.77 | ACHE (0.47) | TLR8TLR7LMNAKDM4ETP53 | |
| SCHEMBL5358672 | 0.77 | ACHE (0.47) | TLR8TLR7LMNAKDM4ETP53 | |
| SCHEMBL5618090 | 0.76 | TLR8 (0.39) | PRMT5TLR8TLR7LMNAHRH4 | |
| SCHEMBL4376577 | 0.74 | EGFR (0.42) | PRMT5HRH4TOP1KDM4ECYP3A4 | |
| SCHEMBL191231 | 0.74 | PRMT5 (0.44) | PRMT5TLR8TLR7LMNAHRH4 | |
| SCHEMBL5356465 | 0.73 | ACHE (0.50) | LMNAKDM4ETP53CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735421-B2 | Imidazoquinolinyl sulfonamides | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-05-27 | — | — | US | disclosed |
| EP-1699788-A2 | IMIDAZOQUINOLINYL, IMIDAZOPYRIDINYL AND IMIDAZONAPHTHYRIDINYL SULFONAMIDES | 3M Innovative Properties Company (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005066169-A2 | IMIDAZOQUINOLINYL, IMIDAZOPYRIDINYL, AND IMIDAZONAPHTHYRIDINYL SULFONAMIDES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |