Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791943 | 1.00 | KDM1A (0.48) | KDM1AHDAC4MEN1KMT2AKCNH2 | |
| SCHEMBL5794479 | 0.81 | XIAP (0.36) | KDM1AHDAC4 | |
| SCHEMBL5791949 | 0.81 | XIAP (0.36) | KDM1AHDAC4 | |
| SCHEMBL5794455 | 0.76 | KDM1A (0.48) | KDM1AHDAC4MEN1KMT2AKCNH2 | |
| SCHEMBL5793810 | 0.75 | KDM1A (0.47) | KDM1AHDAC4 | |
| SCHEMBL5793048 | 0.75 | KDM1A (0.47) | KDM1AHDAC4 | |
| SCHEMBL5764210 | 0.75 | KDM1A (0.52) | KDM1AKCNH2 | |
| SCHEMBL5764222 | 0.75 | KDM1A (0.52) | KDM1AKCNH2 | |
| SCHEMBL5762190 | 0.75 | KDM1A (0.49) | KDM1AKCNH2SCN3AUSP2 | |
| SCHEMBL5793794 | 0.75 | KDM1A (0.49) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |