Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 11/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791949 | 1.00 | XIAP (0.36) | XIAPPSMB5PSMB2TAAR1SMYD3 | |
| SCHEMBL5791943 | 0.81 | KDM1A (0.48) | HDAC4KDM1A | |
| SCHEMBL5794477 | 0.81 | KDM1A (0.48) | HDAC4KDM1A | |
| SCHEMBL4842034 | 0.77 | PSEN1 (0.46) | PSMB5PSMB2 | |
| SCHEMBL4833022 | 0.77 | PSEN1 (0.46) | PSMB5PSMB2 | |
| SCHEMBL4833521 | 0.77 | PSEN1 (0.46) | PSMB5PSMB2 | |
| SCHEMBL4845722 | 0.77 | PSEN1 (0.46) | PSMB5PSMB2 | |
| SCHEMBL4842672 | 0.77 | PSEN1 (0.46) | PSMB5PSMB2 | |
| SCHEMBL4843334 | 0.76 | PSEN1 (0.49) | PSMB5 | |
| SCHEMBL4834282 | 0.76 | PSEN1 (0.49) | PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |