Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27977111 | 1.00 | KDM4E (0.44) | KDM4EMAPK1HIF1APOLBADRA1A | |
| SCHEMBL5791843 | 0.98 | POLB (0.44) | KDM4EMAPK1HIF1APOLBADRA1A | |
| SCHEMBL5794897 | 0.93 | TP53BP1 (0.45) | KDM4EMAPK1HIF1APOLBADRA1A | |
| SCHEMBL354240 | 0.84 | CYP2D6 (0.37) | KDM4EPOLBTP53BP1MEN1KMT2A | |
| SCHEMBL19750417 | 0.83 | KDM4E (0.70) | KDM4EMAPK1HIF1APOLBADRA1A | |
| SCHEMBL18346903 | 0.83 | KDM4E (0.70) | KDM4EMAPK1HIF1APOLBADRA1A | |
| SCHEMBL23975102 | 0.81 | MEN1 (0.48) | KDM4EMAPK1HIF1APOLBTP53BP1 | |
| SCHEMBL5569558 | 0.81 | KDM4E (0.55) | KDM4EMAPK1HIF1APOLBADRA1A | |
| SCHEMBL453216 | 0.81 | KDM4E (0.55) | KDM4EMAPK1HIF1APOLBADRA1A | |
| SCHEMBL20836564 | 0.81 | KDM4E (0.55) | KDM4EMAPK1HIF1APOLBADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |