Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791843 | 0.95 | POLB (0.44) | TP53BP1POLBRAB9AKDM4EMAPK1 | |
| SCHEMBL27977111 | 0.93 | KDM4E (0.44) | TP53BP1POLBRAB9AKDM4EMAPK1 | |
| SCHEMBL5794590 | 0.93 | KDM4E (0.44) | TP53BP1POLBRAB9AKDM4EMAPK1 | |
| SCHEMBL354240 | 0.86 | CYP2D6 (0.37) | TP53BP1POLBRAB9AKDM4EKDM4C | |
| SCHEMBL14043307 | 0.82 | KDM4E (0.58) | TP53BP1POLBKDM4EMAPK1HIF1A | |
| SCHEMBL25942505 | 0.80 | POLB (0.49) | TP53BP1POLBKDM4EMEN1KMT2A | |
| SCHEMBL8958360 | 0.80 | KDM4E (0.43) | POLBKDM4EMAPK1HIF1AMEN1 | |
| SCHEMBL14176518 | 0.78 | CASP2 (0.44) | TP53BP1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL19767693 | 0.78 | TP53BP1 (0.43) | TP53BP1POLBKDM4EMAPK1HIF1A | |
| SCHEMBL20287618 | 0.78 | MEN1 (0.64) | TP53BP1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |