Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.77 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764618 | 1.00 | NOTUM (0.77) | NOTUMXIAPCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL30292335 | 1.00 | NOTUM (0.77) | NOTUMXIAPCYP11B2CYP11B1ALDH1A1 | |
| SCHEMBL24011066 | 0.90 | NOTUM (0.63) | NOTUMLMNACHRM2CHRM3 | |
| SCHEMBL2205988 | 0.87 | NOTUM (1.00) | NOTUMCYP11B2CYP11B1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4108434 | 0.85 | NOTUM (0.55) | NOTUMXIAPALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL30292326 | 0.83 | NOTUM (0.54) | NOTUMXIAPCYP11B2ALDH1A1SMN1; SMN2 | |
| SCHEMBL26691140 | 0.83 | DRD2 (0.54) | NOTUMXIAPALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL6970556 | 0.83 | XIAP (0.57) | NOTUMXIAPSMN1; SMN2LMNADRD2 | |
| SCHEMBL429841 | 0.81 | NOTUM (0.76) | NOTUMXIAPALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8141492 | 0.81 | NOTUM (0.69) | NOTUMALDH1A1SMN1; SMN2LMNADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701954-A1 | N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066165-A1 | N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2005-07-21 | — | — | WO | disclosed |