Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6245467 | 0.84 | NPC1 (0.48) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL5789516 | 0.84 | NPC1 (0.45) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL6243892 | 0.78 | NPC1 (0.48) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL5790301 | 0.78 | NPC1 (0.45) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL5792560 | 0.76 | NPC1 (0.42) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL5789761 | 0.76 | NPC1 (0.45) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL6239280 | 0.76 | NPC1 (0.45) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL5790527 | 0.75 | NPC1 (0.42) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL6245336 | 0.74 | NPC1 (0.44) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL6263397 | 0.73 | RAB9A (0.44) | NPC1RAB9AMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320522-B8 | COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS | LEE MOSES (US) | 2006-02-01 | — | — | EP | disclosed |
| EP-1320522-A2 | COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002030894-A2 | COMPOSITIONS AND METHODS OF THE USE THEREOF ACHIRAL ANALOGUES OF CC-1065 AND THE DUOCARMYCINS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2002-04-18 | — | — | WO | disclosed |