Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794905 | 0.81 | XIAP (0.42) | KDM1A | |
| SCHEMBL5792639 | 0.77 | KDM1A (0.56) | KDM1AHRH3 | |
| SCHEMBL5765661 | 0.75 | KDM1A (0.54) | KDM1ASIGMAR1HTTHRH3 | |
| SCHEMBL5761133 | 0.75 | KDM1A (0.54) | KDM1ASIGMAR1HTTHRH3 | |
| SCHEMBL5762404 | 0.75 | KDM1A (0.54) | KDM1ASIGMAR1HTTHRH3 | |
| SCHEMBL5793048 | 0.74 | KDM1A (0.47) | KDM1ASIGMAR1 | |
| SCHEMBL5793810 | 0.74 | KDM1A (0.47) | KDM1ASIGMAR1 | |
| SCHEMBL5821182 | 0.74 | KDM1A (0.46) | KDM1AHTT | |
| SCHEMBL5792160 | 0.74 | KDM1A (0.46) | KDM1AHTT | |
| SCHEMBL5762783 | 0.73 | KDM1A (0.54) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |