Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792160 | 1.00 | KDM1A (0.46) | KDM1AMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5792162 | 0.81 | XIAP (0.41) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL5806819 | 0.81 | XIAP (0.41) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL5791214 | 0.81 | KDM1A (0.49) | KDM1AMAPTMEN1KMT2ALMNA | |
| SCHEMBL5792552 | 0.81 | KDM1A (0.49) | KDM1AMAPTMEN1KMT2ALMNA | |
| SCHEMBL5791886 | 0.79 | KDM1A (0.47) | KDM1ASMN1; SMN2OPRK1 | |
| SCHEMBL5793421 | 0.74 | KDM1A (0.47) | KDM1AMAPTGAA | |
| SCHEMBL5791529 | 0.74 | KDM1A (0.47) | KDM1AMAPTGAA | |
| SCHEMBL5790510 | 0.74 | KDM1A (0.47) | KDM1AMAPTGAA | |
| SCHEMBL5794903 | 0.74 | KDM1A (0.53) | KDM1AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |