Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20256179 | 0.75 | MCL1 (0.52) | MCL1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL1767738 | 0.74 | CA1 (0.53) | MCL1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL13407614 | 0.74 | MCL1 (0.51) | MCL1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL21800169 | 0.74 | MCL1 (0.51) | MCL1CDK1CCNB1CCNA2CCND1 | |
| SCHEMBL5795158 | 0.74 | CNR2 (0.44) | TRPV4MCL1CDK1CCNB1CCNA2 | |
| SCHEMBL6020640 | 0.72 | SLC22A12 (0.57) | TRPV4PARG | |
| SCHEMBL6038948 | 0.72 | MEN1 (0.46) | TRPV4MCL1CDK1CCNB1CCNA2 | |
| SCHEMBL3691507 | 0.71 | MCL1 (0.52) | MCL1 | |
| SCHEMBL2951564 | 0.70 | MGAM (0.66) | CDK2 | |
| SCHEMBL5796904 | 0.70 | ALDH1A1 (0.42) | TRPV4MCL1ALOX5APFEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006030211-A2 | ACYCLIC SULPHONAMIDES | VERNALIS (R & D) LIMITED (GB) | 2006-03-23 | — | — | WO | disclosed |