Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.72 |
| ▸ | BRD4 | O60885 | 3/20 | 0.60 |
| ▸ | APP | P05067 | 4/20 | 0.49 |
| ▸ | SNCA | P37840 | 3/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943923 | 0.91 | HTR6 (0.81) | HTR6BRD4APPSNCABACE1 | |
| SCHEMBL5792694 | 0.91 | HTR6 (0.81) | HTR6BRD4APPSNCABACE1 | |
| SCHEMBL5795212 | 0.85 | HTR6 (0.72) | HTR6BRD4APPSNCABACE1 | |
| SCHEMBL4941461 | 0.82 | HTR6 (0.71) | HTR6BRD4APPSNCABACE1 | |
| SCHEMBL4942907 | 0.81 | HTR6 (0.67) | HTR6BRD4APPSNCABACE1 | |
| SCHEMBL3862992 | 0.79 | HTR6 (0.63) | HTR6BRD4APPSNCASERPINE1 | |
| SCHEMBL5795018 | 0.78 | HTR6 (0.62) | HTR6BRD4APPSNCANPC1 | |
| SCHEMBL4942869 | 0.78 | HTR6 (0.62) | HTR6BRD4APPSNCANPC1 | |
| SCHEMBL4264252 | 0.77 | HTR6 (0.57) | HTR6BRD4APPSNCABACE1 | |
| SCHEMBL4260047 | 0.77 | HTR6 (0.57) | HTR6BRD4APPSNCABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006525329-A | — | — | 2006-11-09 | — | — | JP | claimed |
| EP-1620420-A2 | SUBSTITUTED CARBOXYLIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004099168-A2 | SUBSTITUTED CARBOXYLIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | claimed |