SCHEMBL5795229

SCHEMBL5795229

NC(=O)[C@H]1CN(c2ccc(C3CCSC(=O)C3)c(F)c2)C(=O)O1

nearest known ligand 0.69

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 0.69
MAOB P27338 5/20 0.39
F10 P00742 7/20 0.36
CALML3 P27482 4/20 0.36
LMNA P02545 1/20 0.36
PTGS1 P23219 1/20 0.36
SDHA P31040 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5795962 0.88 MAOA (0.54) MAOAMAOBF10CALML3LMNA
SCHEMBL3041136 0.87 MAOA (0.78) MAOAMAOBF10CALML3LMNA
SCHEMBL6040286 0.87 MAOA (0.78) MAOAMAOBF10CALML3LMNA
SCHEMBL5792952 0.86 MAOA (0.53) MAOAMAOBF10CALML3LMNA
SCHEMBL3039167 0.86 MAOA (0.87) MAOAMAOBF10CALML3LMNA
SCHEMBL6617227 0.85 MAOA (0.68) MAOAMAOBF10CALML3
SCHEMBL6617949 0.85 MAOA (0.68) MAOAMAOBF10CALML3
SCHEMBL5792580 0.84 MAOA (0.77) MAOAMAOBF10CALML3LMNA
SCHEMBL5738263 0.84 MAOA (0.80) MAOAMAOBF10CALML3LMNA
SCHEMBL4758960 0.83 MAOA (0.74) MAOAMAOBF10CALML3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1478629-B1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN CO LLC (US) 2006-10-11 EP claimed