Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.46 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799064 | 0.85 | RAD52 (0.56) | KDM4EKMT2AMEN1MAPTRAD52 | |
| SCHEMBL13425642 | 0.81 | RAD52 (0.48) | KDM4EKMT2AMEN1MAPTRAD52 | |
| SCHEMBL5799080 | 0.80 | RAD52 (0.46) | KDM4EKMT2AMEN1MAPTRAD52 | |
| SCHEMBL27546693 | 0.80 | KDM4E (0.56) | KDM4EKMT2AMEN1MAPTTSHR | |
| SCHEMBL2445471 | 0.80 | RAD52 (0.47) | KDM4EKMT2AMEN1MAPTRAD52 | |
| Hydrochloric Acid SCHEMBL28301754 | 0.78 | KDM4E (0.55) | KDM4EKMT2AMEN1MAPTTSHR | |
| SCHEMBL15653347 | 0.77 | KDM4E (0.56) | KDM4EKMT2AMEN1MAPTTSHR | |
| SCHEMBL7030506 | 0.77 | KDM4E (0.56) | KDM4EKMT2AMEN1TSHRLMNA | |
| SCHEMBL16234345 | 0.76 | KDM4E (0.51) | KDM4EKMT2AMEN1MAPTTSHR | |
| SCHEMBL3722173 | 0.74 | KDM4E (0.60) | KDM4EKMT2AMEN1MAPTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006040650-A1 | 4-METHOXYACRIDINE-1-CARBOXAMIDE DERIVATIVES AND THE PHENAZINE AND OXANTHRENE ANALOGS AS PDE4-INHIBITORS FOR THE TREATMENT OF ASTHMA AND CHRONIC PULMONARY DISEASE (COPD) | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-04-20 | — | — | WO | disclosed |